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Pregnancy: Female patients of childbearing age should be told about the consequences of second- and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester.
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No overall differences in effectiveness or safety were observed between these patients and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
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Other exclusion criteria included any serious disorder that could limit the ability of the patient to participate in the trial, significant cardiovascular disease within the previous 6 months, and secondary hypertension.
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These differences were not statistically significant at 8 weeks.
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So there is no study of direct but since both of the medicines create hypotension it is better not to use both the medicines together unless your doctor has prescribed after physical examination.
Extrapolating from the observed data, we estimate that this reduction corresponds to an average delay of two years in the need for dialysis or transplantation.
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Cozaar has the same active ingredient as the global generic.
But over the next three years, 604 families joined the study, with results expected in the coming months.
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However, when a medication is administered via other (such as orally), its bioavailability generally decreases (due to incomplete absorption and ) or may vary from patient to patient.
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Figure 2 Cumulative Proportions of Patients with the Primary Composite End Point (Panel A) and Its Components, a Doubling of the Base-Line Serum Creatinine Concentration (Panel B), End-Stage Renal Disease (Panel C), and Death from Any Cause (Panel D).
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The proportions of patients in each group who reached the primary end point are shown in Figure 2 Cumulative Proportions of Patients with the Primary Composite End Point (Panel A) and Its Components, a Doubling of the Base-Line Serum Creatinine Concentration (Panel B), End-Stage Renal Disease (Panel C), and Death from Any Cause (Panel D).
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Meier curves were used to illustrate risk development during follow-up.
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Patients who were prescribed vitamin K antagonists, digitalis glycosides, or nitrates within 15 months prior to the index prescription were also considered to have potential CVD and were excluded.
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The observation made in several clinical trials that small differences in both DBP and SBP are associated with substantial reductions in the incidence of major cardiovascular events suggests that small differences in blood pressure reduction between ARBs may have important long-term effects.
Losartan is a tablet that is taken by mouth with or without food.
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Many people wonder, "What is losartan used for?
Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.
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Figure 4: Kaplan-Meier curve for the primary composite endpoint of doubling of serum creatinine, end stage renal disease (need for dialysis or transplantation) or death.
Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen.
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These drugs include: Candesartan (Atacand); Eprosartan (Tevetan); Irbesartan (Avapro); Losartan (Cozaar); Telmisartan (Mycardis); Valsartan (Diovan).
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Hemodynamic and functional indices of prognosis and comorbid conditions help identify patients who are likely to derive the maximum benefit from transplantation ().
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Furthermore, candesartan has reported positive effects on risk markers such as high oxidative stress and increased coagulability compared to losartan, which may explain the lower risk for CVD complications.
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Mean peak concentrations of Losartan and its active metabolite are reached in 1 hour and in 3 to 4 hours, respectively.
Systemic bioavailability is about 33%.
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There was a small, time-averaged difference in the trough blood pressure between the losartan group and the placebo group.
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Enthusiasm for long-term intermittent or continuous infusion has been tempered by a number of studies showing increased mortality with no significant morbidity benefits, similar to findings with a number of oral inotropes ().
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See a complete list of ingredients in losartan potassium and hydrochlorothiazide tablets at the end of this leaflet.
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