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The institutional review board or ethics committee of each center approved the protocol, and all patients gave written informed consent after reviewing a written summary of the study plan.

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Food decreases absorption but has only minor effects on losartan AUC or AUC of active metabolite.

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Figure 1: Kaplan-Meier estimates of the primary endpoint of time to cardiovascular death, nonfatal stroke, or nonfatal myocardial infarction in the groups treated with Losartan and atenolol.

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Change in least squares mean 24-hour diastolic (DBP) and systolic blood pressure (SBP) from baseline after 8 weeks of treatment with olmesartan, losartan, valsartan, and irbesartan.

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Because the study was designed to achieve equal blood pressure control in both groups, other antihypertensive agents (diuretics, calcium-channel blockers, alpha- or beta-blockers, and centrally acting agents) could be added as needed in both groups.

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